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lymphoma
In this image, the proteasome—a cell’s protein disposal system—is shown in tan and grey. A protein called midnolin (in red) connects with two key parts of the proteasome, RPN1 (blue) and RPN11 (green), to help deliver damaged or unwanted proteins for breakdown. This interaction helps keep cells healthy by clearing out the cellular junk. [Image: UTSW]
UT Southwestern Maps a Cancer-Enabling Protein That Lets B-Cell Tumors Hang On—With a Nobel Laureate on the Case
by Lance Murray | Jun 16, 2025
The protein—implicated in blood cancers like leukemia, lymphoma, and multiple myeloma—was decoded in near-atomic detail by UT Southwestern researchers, including Nobel Prize winner Bruce Beutler. In lab models, turning off midnolin wiped out up to 92% of cancer cells—with minimal impact on healthy ones, according to UT Southwestern.
by David Seeley |
Aug 6, 2024
A study co-led by UTSW's Jin Huk Choi, Ph.D., and Nobel Prize winner Bruce Beutler, M.D., found that targeting a gene-produced protein called ZFP574 "reduced the amount of malignant B cells by as much as 92%." Their findings could lead to new treatments for leukemias and lymphomas—and potentially other cancers, too.
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